Xiao Yang*, Xiangdong Zhu1*, Xingdong Zhang1*

1Sichuan University, Chengdu, 610064, China

EXTENDED ABSTRACT: Based on the originally developed tumor suppressive/tissue regenerative material data base, the researcher has screened out specific hydroxyapatite nanoparticles which presented both anti-tumor and bone regenerative abilities. High-throughput technologies was equipped to assist calcium phosphate based bioceramics fabrication. A series of bone repair materials were then developed by the researcher with therapeutic functions aiming to be applied in osteoporosis or osteosarcoma caused bone defects. Micro/nano-level mechanics of the materials was studied when implanted into the diseased host

bone. The essential material and biological factors were elucidated. These materials showed promising in vivo results in tumor suppression and bone regeneration,even without addition of drug treatment A systematic approach for biomaterial assessment and in vivo behavior prediction was built through data mining, toguide bioceramics design and optimization. As a team,these work were published in high impact journals including Science Advances, Biomaterials, ACS Appl Mater Inter, Nano Research etc. They were widely reported by several news media, including Science News Agency, CCTV and proceedings of Chinese Academy of Engineering. Currently, several clinical trials were launching with some of these new functional bone repair materials.

Keywords: High-throughput technology; Database; antitumor; nanoparticles.