Abstract: Metallic glasses are a broad and relatively young materials class which exhibit superior mechanical properties and unique processability. Previously, they have been developed through trial-and-error methods that revealed a range of glass-forming alloys, but only a small fraction when compared to estimations. For example, there exist no bulk metallic glasses with glass transition temperature, Tg, exceeding 1000 K. Hence, their application temperature range is very narrow. In this talk, we demonstrate that we can develop bulk metallic glasses with specific properties, using a combination of materials design, combinatorial fabrication, and high-throughput characterization. Specifically, we report the development of Ir-Ni-Ta-(B) bulk metallic glasses that exhibit Tg as high as 1162 K and ΔT as wide as 136 K. The glasses exhibit an exceptional combination of properties, such as unprecedented strength of 3.7 GPa at temperature over 1000 K, high glass forming ability and thermal plastic formability, low thermal expansion coefficient of 6.5×10-6 K-1, remarkable hardness of 15 GPa and Young’s modulus of 263 GPa, high-temperature oxidation resistance, and superior corrosion resistance even in aqua regia. The developed Ir-Ni-Ta-(B) alloys exemplifies the breadth of metallic glasses expanding into high temperature, and demonstrate the effectiveness and efficiency of combinatorial approaches to design and discover glassy materials with specific properties.